Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current
<i>I</i>
<sub/>Ks</sub>
by (
<i>R</i>
)-2-(2,4- Trifluoromethyl)-
<i>N</i>
-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1
<i>H</i>
-benzo[
<i>e</i>
][1,4]diazepin-3-yl]acetamide

Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current I _Ks by ( R )-2-(2,4- Trifluoromethyl)- N -[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1 H -benzo[ e ][1,4]diazepin-3-yl]acetamide

Selnick, Harold G.; Liverton, Nigel J.; Baldwin, John J.; Butcher, John W.; Claremon, David A.; Elliott, Jason M.; Freidinger, Roger M.; King, Stella A.; Libby, Brian E.; McIntyre, Charles J.; Pribush, David A.; Remy, David C.; Smith, Garry R.; Tebben, Andrew J.; Jurkiewicz, Nancy K.; Lynch, Joseph J.; Salata, Joseph J.; Sanguinetti, Michael C.; Siegl, Peter K. S.; Slaughter, Donald E.; Vyas, Kamlesh

期刊名称Journal of Medicinal Chemistry
作者Selnick, Harold G.; Liverton, Nigel J.; Baldwin, John J.; Butcher, John W.; Claremon, David A.; Elliott, Jason M.; Freidinger, Roger M.; King, Stella A.; Libby, Brian E.; McIntyre, Charles J.; Pribush, David A.; Remy, David C.; Smith, Garry R.; Tebben, Andrew J.; Jurkiewicz, Nancy K.; Lynch, Joseph J.; Salata, Joseph J.; Sanguinetti, Michael C.; Siegl, Peter K. S.; Slaughter, Donald E.; Vyas, Kamlesh
卷第40卷
期第24期
印刷ISSN0022-2623
电子ISSN1520-4804
文件大小99.52KB
发表时间1997-11
DOI10.1021/jm970517u
页码3865-3868

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Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current I Ks by ( R )-2-(2,4- Trifluoromethyl)- N -[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1 H -benzo[ e ][1,4]diazepin-3-yl]acetamide

Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current I _Ks by ( R )-2-(2,4- Trifluoromethyl)- N -[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1 H -benzo[ e ][1,4]diazepin-3-yl]acetamide