Discovery of a Potent and Selective Prostaglandin D
<sub/>2</sub>
Receptor Antagonist, [(3
<i>R</i>
)-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[
<i>b</i>
]indol-3-yl]-acetic Acid (MK-0524)
<sup>†</sup>

Discovery of a Potent and Selective Prostaglandin D ₂ Receptor Antagonist, [(3 R )-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[ b ]indol-3-yl]-acetic Acid (MK-0524) ^†

Sturino, Claudio F.; O'Neill, Gary; Lachance, Nicolas; Boyd, Michael; Berthelette, Carl; Labelle, Marc; Li, Lianhai; Roy, Bruno; Scheigetz, John; Tsou, Nancy; Aubin, Yves; Bateman, Kevin P.; Chauret, Nathalie; Day, Stephen H.; Lévesque, Jean-François; Seto, Carmai; Silva, Jose H.; Trimble, Laird A.; Carriere, Marie-Claude; Denis, Danielle; Greig, Gillian; Kargman, Stacia; Lamontagne, Sonia; Mathieu, Marie-Claude; Sawyer, Nicole; Slipetz, Deborah; Abraham, William M.; Jones, Tom; McAuliffe, Malia; Piechuta, Hana; Nicoll-Griffith, Deborah A.; Wang, Zhaoyin; Zamboni, Robert; Young, Robert N.; Metters, Kathleen M.

期刊名称Journal of Medicinal Chemistry
作者Sturino, Claudio F.; O'Neill, Gary; Lachance, Nicolas; Boyd, Michael; Berthelette, Carl; Labelle, Marc; Li, Lianhai; Roy, Bruno; Scheigetz, John; Tsou, Nancy; Aubin, Yves; Bateman, Kevin P.; Chauret, Nathalie; Day, Stephen H.; Lévesque, Jean-François; Seto, Carmai; Silva, Jose H.; Trimble, Laird A.; Carriere, Marie-Claude; Denis, Danielle; Greig, Gillian; Kargman, Stacia; Lamontagne, Sonia; Mathieu, Marie-Claude; Sawyer, Nicole; Slipetz, Deborah; Abraham, William M.; Jones, Tom; McAuliffe, Malia; Piechuta, Hana; Nicoll-Griffith, Deborah A.; Wang, Zhaoyin; Zamboni, Robert; Young, Robert N.; Metters, Kathleen M.
卷第50卷
期第4期
印刷ISSN0022-2623
电子ISSN1520-4804
文件大小164.54KB
发表时间2007-02
DOI10.1021/jm0603668
页码794-806

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Discovery of a Potent and Selective Prostaglandin D 2 Receptor Antagonist, [(3 R )-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[ b ]indol-3-yl]-acetic Acid (MK-0524) †

Discovery of a Potent and Selective Prostaglandin D ₂ Receptor Antagonist, [(3 R )-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[ b ]indol-3-yl]-acetic Acid (MK-0524) ^†