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- 作者Austin, Thomas H.; Flanagan, Cormac
- 文件大小261.16KB
- 发表时间2009
- DOI10.1145/1554339.1554353
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Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer.Elahmad, Youssef; TABART, MICHEL; Halley, Frank; Certal, Victor; Thompson, Fabienne; Filoche-Romme, Bruno; Gruss-Leleu, Florence; Muller, Claire; Brollo, Maurice; Fabien, Laurence; Loyau, Veronique; Bertin, Luc; Richepin, Patrick; Pilorge, Fabienne; Desmazeau, Pascal; Girardet, Chrystelle; Beccari, Sylvie; Louboutin, Audrey; Lebourg, Gilles; Le-Roux, Jacques; Terrier, Corinne; Vallée, François; Steier, Valerie; Mathieu, Magali; Rak, Alexey; Abecassis, Pierre-Yves; Vicat, Pascale; Benard, Tsiala; Bouaboula, Monsif; Sun, Fangxian; Shomali, Maysoun; Hebert, Andrew; Levit, Mikhail; Cheng, Hong; Courjaud, Albane; Ginesty, Celine; Perrault, Christelle; Garcia-Echeverria, Carlos; McCort, Gary; Schio, Laurent · Journal of Medicinal Chemistry · 2019