Selective Class I Phosphoinositide 3-Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511

• 期刊名称Journal of Medicinal Chemistry
• 作者Norman, Mark H.; Andrews, Kristin L.; Bo, Yunxin Y.; Booker, Shon K.; Caenepeel, Sean; Cee, Victor J.; D’Angelo, Noel D.; Freeman, Daniel J.; Herberich, Bradley J.; Hong, Fang-Tsao; Jackson, Claire L. M.; Jiang, Jian; Lanman, Brian A.; Liu, Longbin; McCarter, John D.; Mullady, Erin L.; Nishimura, Nobuko; Pettus, Liping H.; Reed, Anthony B.; Miguel, Tisha San; Smith, Adrian L.; Stec, Markian M.; Tadesse, Seifu; Tasker, Andrew; Aidasani, Divesh; Zhu, Xiaochun; Subramanian, Raju; Tamayo, Nuria A.; Wang, Ling; Whittington, Douglas A.; Wu, Bin; Wu, Tian; Wurz, Ryan P.; Yang, Kevin; Zalameda, Leeanne; Zhang, Nancy; Hughes, Paul E.
• 卷第55卷
• 期第17期
• 印刷ISSN0022-2623
• 电子ISSN1520-4804
• 文件大小3769.95KB
• 发表时间2012-09-13
• DOI10.1021/jm300846z
• 页码7796-7816