Aldehyde Tag Coupled with HIPS Chemistry Enables the Production of ADCs Conjugated Site-Specifically to Different Antibody Regions with Distinct in Vivo Efficacy and PK Outcomes

Drake, Penelope M.; Albers, Aaron E.; Baker, Jeanne; Banas, Stefanie; Barfield, Robyn M.; Bhat, Abhijit S.; de Hart, Gregory W.; Garofalo, Albert W.; Holder, Patrick; Jones, Lesley C.; Kudirka, Romas; McFarland, Jesse; Zmolek, Wes; Rabuka, David

期刊名称Bioconjugate Chemistry
作者Drake, Penelope M.; Albers, Aaron E.; Baker, Jeanne; Banas, Stefanie; Barfield, Robyn M.; Bhat, Abhijit S.; de Hart, Gregory W.; Garofalo, Albert W.; Holder, Patrick; Jones, Lesley C.; Kudirka, Romas; McFarland, Jesse; Zmolek, Wes; Rabuka, David
卷第25卷
期第7期
印刷ISSN1043-1802
电子ISSN1520-4812
文件大小2485.66KB
发表时间2014-07-16
DOI10.1021/bc500189z
页码1331-1341

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Aldehyde Tag Coupled with HIPS Chemistry Enables the Production of ADCs Conjugated Site-Specifically to Different Antibody Regions with Distinct in Vivo Efficacy and PK Outcomes