PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas

Lu, Hezhe; Liu, Shujing; Zhang, Gao; Bin Wu, ; Zhu, Yueyao; Frederick, Dennie T.; Hu, Yi; Zhong, Wenqun; Randell, Sergio; Sadek, Norah; Zhang, Wei; Chen, Gang; Cheng, Chaoran; Zeng, Jingwen; Wu, Lawrence W.; Zhang, Jie; Liu, Xiaoming; Xu, Wei; Krepler, Clemens; Sproesser, Katrin; Xiao, Min; Miao, Benchun; Liu, Jianglan; Song, Claire D.; Liu, Jephrey Y.; Karakousis, Giorgos C.; Schuchter, Lynn M.; Lu, Yiling; Mills, Gordon; Cong, Yusheng; Chernoff, Jonathan; Guo, Jun; Boland, Genevieve M.; Sullivan, Ryan J.; Wei, Zhi; Field, Jeffrey; Amaravadi, Ravi K.; Flaherty, Keith T.; Herlyn, Meenhard; Xu, Xiaowei; Guo, Wei

期刊名称Nature
作者Lu, Hezhe; Liu, Shujing; Zhang, Gao; Bin Wu, ; Zhu, Yueyao; Frederick, Dennie T.; Hu, Yi; Zhong, Wenqun; Randell, Sergio; Sadek, Norah; Zhang, Wei; Chen, Gang; Cheng, Chaoran; Zeng, Jingwen; Wu, Lawrence W.; Zhang, Jie; Liu, Xiaoming; Xu, Wei; Krepler, Clemens; Sproesser, Katrin; Xiao, Min; Miao, Benchun; Liu, Jianglan; Song, Claire D.; Liu, Jephrey Y.; Karakousis, Giorgos C.; Schuchter, Lynn M.; Lu, Yiling; Mills, Gordon; Cong, Yusheng; Chernoff, Jonathan; Guo, Jun; Boland, Genevieve M.; Sullivan, Ryan J.; Wei, Zhi; Field, Jeffrey; Amaravadi, Ravi K.; Flaherty, Keith T.; Herlyn, Meenhard; Xu, Xiaowei; Guo, Wei
印刷ISSN0028-0836
电子ISSN1476-4687
文件大小12924.97KB
发表时间2017-9-27
DOI10.1038/nature24040

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PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas