Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase γ Inhibitors (PI3Kγ) with Potential for the Treatment of Multiple Sclerosis (MS)

Come, Jon H; Collier, Philip N; Henderson, James A; Pierce, Albert C; Davies, Robert J; Le Tiran, Arnaud; O'Dowd, Hardwin; Bandarage, Upul K.; Cao, Jingrong; Deininger, David; Grey, Ron; Krueger, Elaine B.; Lowe, Derek Bates; Liang, Jianglin; Liao, Yusheng; Messersmith, David; Nanthakumar, Suganthi; Sizensky, Emmanuelle; Wang, Jian; Xu, Jinwang; Chin, Elaine Y; Damagnez, Veronique; Doran, John D.; Dworakowski, Wojciech; Griffith, James P; Jacobs, Marc D.; Khare-Pandit, Suvarna; Mahajan, Sudipta; Moody, Cameron S.; Aronov, Alex M.

期刊名称Journal of Medicinal Chemistry
作者Come, Jon H; Collier, Philip N; Henderson, James A; Pierce, Albert C; Davies, Robert J; Le Tiran, Arnaud; O'Dowd, Hardwin; Bandarage, Upul K.; Cao, Jingrong; Deininger, David; Grey, Ron; Krueger, Elaine B.; Lowe, Derek Bates; Liang, Jianglin; Liao, Yusheng; Messersmith, David; Nanthakumar, Suganthi; Sizensky, Emmanuelle; Wang, Jian; Xu, Jinwang; Chin, Elaine Y; Damagnez, Veronique; Doran, John D.; Dworakowski, Wojciech; Griffith, James P; Jacobs, Marc D.; Khare-Pandit, Suvarna; Mahajan, Sudipta; Moody, Cameron S.; Aronov, Alex M.
印刷ISSN0022-2623
电子ISSN1520-4804
文件大小895.09KB
发表时间2018-05-30
DOI10.1021/acs.jmedchem.8b00085

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Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase γ Inhibitors (PI3Kγ) with Potential for the Treatment of Multiple Sclerosis (MS)