Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generationAirola, Michael V.; Shanbhogue, Prajna; Shamseddine, Achraf A.; Guja, Kip E.; Senkal, Can E.; Maini, Rohan; Bartke, Nana; Wu, Bill X.; Obeid, Lina M.; Garcia-Diaz, Miguel; Hannun, Yusuf A. · Proceedings of the National Academy of Sciences · 2017

The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzymeShanbhogue, Prajna; Hoffmann, Reece M.; Airola, Michael V.; Maini, Rohan; Hamelin, David J.; Garcia-Diaz, Miguel; Burke, John E.; Hannun, Yusuf A. · Journal of Biological Chemistry · 2019

Alternate Splicing of Dysferlin C2A Confers Ca2+-Dependent and Ca2+-Independent Binding for Membrane RepairFuson, Kerry; Rice, Anne; Mahling, Ryan; Snow, Adam; Nayak, Kamakshi; Shanbhogue, Prajna; Meyer, Austin G.; Redpath, Gregory M.I.; Hinderliter, Anne; Cooper, Sandra T.; Sutton, R. Bryan · Structure · 2014